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Organometallic compounds contain direct bonds between carbon atoms and metal atoms/ions and play roles as homogeneous catalysts and stoichiometric reagents in reactions; available in various chemical compositions, quantities, purities, and reagent grades.
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PS-1145 (CAS 431898-65-6) is a selective inhibitor of I B kinase (IKK) with an IC50 of 88 nM IKK is a critical component of the upstream NF- B signaling pathway regulating cellular responses to inflammation In vitro studies have demonstrated that PS-1145 blocks TNF -induced NF- B activation in multiple myeloma (MM) cells in a dose- and time-dependent manner increases I B protein levels suppresses IL-6-mediated anti-apoptotic effects and inhibits expression of ICAM-1 Additionally PS-1145 reduces IL-6 secretion from bone marrow stromal cells (BMSCs) and partially limits MM cell proliferation In vivo PS-1145 has been shown to induce apoptosis in DMBA-induced skin tumors in rats by inhibiting NF- B and VEGF activity The compound remains in the preclinical research stage
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
PS-1145 is a small-molecule inhibitor of IκB kinase (IKK) used in research to block NF-κB signaling and induce apoptosis in cell models. It is supplied as a powder with documented solubility and storage recommendations for experimental use.
Potent IKK inhibitor with IC50 of 88 nM.
High chemical purity (99.88%).
Provided as a powder for convenient handling and formulation.
Soluble in DMSO at 20.83 mg/mL; multiple in vitro formulations available.
Stable under recommended storage conditions for long-term use.
Suitable for in vitro studies of NF-κB signaling and apoptosis pathways.
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